Evolution of Antibodies to Epitopes of PE_PGRS51 in the Spectrum of Active Pulmonary Tuberculosis

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Abstract
Background: Intrafamily homology has impeded correlation of expression of individual PE_PGRS proteins with stage of tuberculosis (TB). We investigated the in vivo expression of PE_PGRS51, which has 3 unique regions. Methods: Sera from patients across the spectrum of TB were used to screen peptide arrays spanning PE_PGRS51. Results: Antibodies against a subset of conserved “core epitopes” within PE/PGRS domains are elicited during early TB. The epitope repertoire expands to adjacent regions with disease progression. Antiunique region antibodies appear only during cavitary TB. Conclusions: Elicitation of antiunique region antibodies can serve as markers for in vivo expression of PE_PGRS proteins.
Funding Information
  • National Institutes of Health (HL094826)

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