Plumbagin inhibits CYP2J/EETs metabolic pathway and leads to heart injury in cardiac organoids and rats
Authors:
- 28 August 2025
- journal article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 242, 117282
Abstract
No abstract availableKeywords
Funding Information
- Science and Technology Commission of Shanghai Municipality (CNKW2024Y34, RCJD2022S06)
- East China Normal University
This publication has 35 references indexed in Scilit:
- Development of human embryonic stem cell-derived cardiomyocytes and application of fluorescence probe substrate for characterization of cytochrome P450 enzyme 2J2Drug Metabolism and Disposition, 2025
- Astaxanthin ameliorated isoproterenol induced myocardial infarction via improving the mitochondrial function and antioxidant activity in ratsJournal of Biochemical and Molecular Toxicology, 2024
- Sorafenib reduces the production of epoxyeicosatrienoic acids and leads to cardiac injury by inhibiting CYP2J in ratsBiochemical Pharmacology, 2024
- A Comprehensive Overview on Chemotherapy-Induced Cardiotoxicity: Insights into the Underlying Inflammatory and Oxidative MechanismsCardiovascular Drugs and Therapy, 2024
- Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative Stress, preventing inflammation and apoptosis: Ultrastructural and computational approachesHeliyon, 2024
- Assessment of doxorubicin toxicity using human cardiac organoids: A novel model for evaluating drug cardiotoxicityChemico-Biological Interactions, 2023
- Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic heartsActa Pharmaceutica Sinica B, 2022
- Plumbagin induces testicular damage via mitochondrial-dependent cell deathChemico-Biological Interactions, 2021
- Plumbagin protects the myocardial damage by modulating the cardiac biomarkers, antioxidants, and apoptosis signaling in the doxorubicin‐induced cardiotoxicity in ratsEnvironmental Toxicology, 2020
- Inhibition and inactivation of human CYP2J2: Implications in cardiac pathophysiology and opportunities in cancer therapyBiochemical Pharmacology, 2017