Genetically AttenuatedPlasmodium bergheiLiver Stages Induce Sterile Protracted Protection That Is Mediated by Major Histocompatibility Complex Class I–Dependent Interferon‐γ–Producing CD8+T Cells
Open Access
- 15 August 2007
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 196 (4) , 599-607
Abstract
At present, radiation-attenuated plasmodia sporozoites (γ-spz) is the only vaccine that induces sterile and lasting protection in malaria-naive humansKeywords
This publication has 27 references indexed in Scilit:
- Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cellsProceedings of the National Academy of Sciences, 2005
- Plasmodium liver stage developmental arrest by depletion of a protein at the parasite–host interfaceProceedings of the National Academy of Sciences, 2005
- The Dissection of CD8 T Cells During Liver-Stage Infection2005
- Genetically modified Plasmodium parasites as a protective experimental malaria vaccineNature, 2004
- MHC class I-dependent presentation of exoerythrocytic antigens to CD8+ T lymphocytes is required for protective immunity against Plasmodium bergheiThe Journal of Immunology, 1996
- Irradiated sporozoite vaccine induces HLA-B8-restricted cytotoxic T lymphocyte responses against two overlapping epitopes of the Plasmodium falciparum sporozoite surface protein 2.Journal of Experimental Medicine, 1995
- Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites.Proceedings of the National Academy of Sciences, 1995
- Humoral Immune Responses in Volunteers Immunized with Irradiated Plasmodium falciparum SporozoitesThe American Journal of Tropical Medicine and Hygiene, 1993
- T Cell Responses to Pre-Erythrocytic Stages of Malaria: Role in Protection and Vaccine Development Against Pre-Erythrocytic StagesAnnual Review of Immunology, 1993
- Protection against malaria induced by irradiated sporozoitesThe Lancet, 1990