Primary amine-catalysis enables stereoselective synthesis of chiral hydrindanone-based motifs as electrophilic scaffolds for covalent protein-labeling
- 27 October 2026
- journal article
- Published by Royal Society of Chemistry (RSC) in Organic Chemistry Frontiers
- Vol. 13 (21) , 7441-7447
Abstract
An enantioselective eliminative inverse electron-demand Diels–Alder reaction of α-branched aldehydes, providing hydrindanone scaffolds in high yields and enantioselectivities, enabled by a cinchona alkaloid-based primary amine catalyst is reported.Keywords
Funding Information
- Danmarks Frie Forskningsfond (2032-00165B)
- Aarhus Universitet
- Carlsbergfondet (CF24-2082)
- Carlsbergfondet (CF24-1658)
- Novo Nordisk Fonden (NNF21OC0072047, NNF25OC0102763)
- Villum Fonden (25867)
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