Maturity-onset Diabetes of the Young (MODY) in Pregnancy: A Review
- 1 January 2023
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Current Diabetes Reviews
- Vol. 19 (1) , 1
Abstract
Hyperglycaemia in pregnancy is one of the most common complications of pregnancy and is generally diagnosed as gestational diabetes mellitus (GDM). Nevertheless, clinical symptoms of hyperglycaemia in pregnancy in some cases do not match the clinical manifestations of GDM. It is suspected that 1-2 % of women diagnosed with GDM are misdiagnosed maturity-onset diabetes of the young (MODY). MODY often has a subclinical course; thus, it is challenging for clinicians to aptly diagnose monogenic diabetes in pregnancy. Proper diagnosis is crucial for the effective treatment of hyperglycaemia in pregnancy. Many studies revealed that misdiagnosis of MODY increases the rate of complications for both mother and fetus. This literature review reports the current knowledge regarding diagnosis, treatment, and complications of the most common types of MODY in pregnancy.Keywords
This publication has 30 references indexed in Scilit:
- Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Common Genetic Variants in GCK and TCF7L2 Are Associated With Fasting and Postchallenge Glucose Levels in Pregnancy and With the New Consensus Definition of Gestational Diabetes Mellitus From the International Association of Diabetes and Pregnancy Study GroupsDiabetes, 2010
- Maturity onset diabetes of the young and pregnancyBest Practice & Research Clinical Endocrinology & Metabolism, 2010
- Pregnancy outcome in patients with raised blood glucose due to a heterozygous glucokinase gene mutationDiabetic Medicine, 2009
- Persistent Hyperinsulinemic Hypoglycemia and Maturity-Onset Diabetes of the Young Due to Heterozygous HNF4A MutationsDiabetes, 2008
- Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A GenePLOS Medicine, 2007
- Hepatocyte nuclear factor‐1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF‐1β in human pancreatic developmentDiabetic Medicine, 2006
- Glyburide for the management of gestational diabetes: Risk factors predictive of failure and associated pregnancy outcomesAmerican Journal of Obstetrics and Gynecology, 2006
- IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetesMetabolism, 2005
- Intrauterine Hyperglycemia Is Associated With an Earlier Diagnosis of Diabetes in HNF-1α Gene Mutation CarriersDiabetes Care, 2002
- Determinants of the Development of Diabetes (Maturity-Onset Diabetes of the Young-3) in Carriers of HNF-1α MutationsDiabetes Care, 2002