EFFECT OF METHYLENE BLUE ON THE DISPOSITION OF ETHANOL
Authors:
Open Access
- 1 September 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Alcohol and Alcoholism
- Vol. 35 (5) , 424-426
Abstract
The effect of methylene blue on the disposition of ethanol was studied in rats and humans. Methylene blue increased the metabolism of [14C]ethanol to 14CO2 in isolated hepatocytes and in intact rats by 75% and 30%, respectively. In healthy volunteers, methylene blue did not affect the pharmacokinetics of ethanol and did not alleviate the ethanol-induced NAD redox changes as reflected by the increase in the [lactate]/[pyruvate] ratio.Keywords
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