Cold acclimation and pioglitazone combined increase thermogenic capacity of brown and white adipose tissues but this does not translate into higher energy expenditure in mice

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Abstract
Cold acclimation and PPARγ agonism combined markedly increase brown and white adipose tissue total UCP1 content and mRNA levels of thermogenesis-related proteins. Higher UCP1 protein levels did not result in higher energy expenditure. The high thermogenic capacity induced by PPARγ agonism in cold-exposed animals markedly increases animals' body temperature in response to the β3-adrenergic agonist CL316,243.
Funding Information
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2021/02953-1)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2021/03717-0)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2019/01763-4)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2020/04159-8)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2018/14728-0)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2017/24615-5)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2017/26651-9)
  • MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico (303078/2019-7)
  • MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico (428754/2018-0)

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