2-Aminopyrimidine-4,6-diol as an Efficient Ligand for Solvent-Free Copper-Catalyzed N-Arylations of Imidazoles with Aryl and Heteroaryl Halides
Authors:
- 20 September 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 71 (21) , 8324-8327
Abstract
Efficient and solvent-free copper-catalyzed N-arylations of imidazoles with aryl and heteroaryl halides have been demonstrated. In the presence of CuBr, 2-aminopyrimidine-4,6-diol, and TBAF (n-Bu4NF), a variety of imidazoles underwent the N-arylation reaction with aryl and heteroaryl halides smoothly in moderate to excellent yields. Noteworthy is that the reaction is conducted under solvent-free conditions.Keywords
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