Safety and Activity of the Immune Modulator HE2000 on the Incidence of Tuberculosis and Other Opportunistic Infections in AIDS Patients
- 1 July 2007
- journal article
- clinical trial
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 51 (7) , 2639-2641
Abstract
Twenty-five AIDS patients were treated with HE2000, a synthetic adrenal hormone. The drug was well tolerated and safe and reduced both the incidence of tuberculosis coinfection by 42.2% ( P < 0.05) and the cumulative incidence of opportunistic infections ( P < 0.05). These results warrant further clinical investigation of HE2000.Keywords
This publication has 14 references indexed in Scilit:
- REDUCTION OF PARASITE LEVELS IN PATIENTS WITH UNCOMPLICATED MALARIA BY TREATMENT WITH HE2000The American Journal of Tropical Medicine and Hygiene, 2007
- Improvement in immune parameters and human immunodeficiency virus-1 viral response in individuals treated with 16α-bromoepiandrosterone (HE2000)Clinical Microbiology and Infection, 2006
- 16α‐Bromoepiandrosterone Restores T Helper Cell Type 1 Activity and Accelerates Chemotherapy‐Induced Bacterial Clearance in a Model of Progressive Pulmonary TuberculosisThe Journal of Infectious Diseases, 2005
- 16α-Bromo-epiandrosterone therapy modulates experimental feline immunodeficiency virus viremia: initial enhancement leading to long-term suppressionVeterinary Immunology and Immunopathology, 2003
- 16α-Bromoepiandrosterone, an Antimalarial Analogue of the Hormone Dehydroepiandrosterone, Enhances Phagocytosis of Ring Stage Parasitized Erythrocytes: a Novel Mechanism for Antimalarial ActivityAntimicrobial Agents and Chemotherapy, 2002
- Decreased Interferon-α Production in HIV-Infected Patients Correlates with Numerical and Functional Deficiencies in Circulating Type 2 Dendritic Cell PrecursorsClinical Immunology, 2001
- Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patientsBlood, 2001
- 16alpha-bromoepiandrosterone, a dehydroepiandrosterone (DHEA) analogue, inhibits Plasmodium falciparum and Plasmodium berghei growth.The American Journal of Tropical Medicine and Hygiene, 2000
- Semiparametric Regression for the Mean and Rate Functions of Recurrent EventsJournal of the Royal Statistical Society Series B: Statistical Methodology, 2000
- Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity.Journal of Clinical Investigation, 1986