MicroRNAs in T Cell-Immunotherapy

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Abstract
MicroRNAs (miRNAs) act as master regulators of gene expression in homeostasis and disease. Despite the rapidly growing body of evidence on the theranostic potential of restoring miRNA levels in pre-clinical models, the translation into clinics remains limited. Here, we review the current knowledge of miRNAs as T-cell targeting immunotherapeutic tools, and we offer an overview of the recent advances in miRNA delivery strategies, clinical trials and future perspectives in RNA interference technologies.
Funding Information
  • Spanish Ministry of Economy and Competitiveness (AEI/10.13039/501100011033, PID-2020-120412RB-I100, PDC2021-121797-I00)
  • Comunidad de Madrid (S2017/BMD-3671-INFLAMUNE-CM)
  • Instituto de Salud Carlos “la Caixa” (CB16/11/00272, BIOIMID PIE13/041, HR17-00016)
  • AECC-Coordinated (PRYCO223002PEIN)
  • Ministerio de Ciencia, Innovación y Universidades (SEV-2015-0505)
  • ‘Severo Ochoa’ Programme for Centres of Excellence in R&D (CEX2020-001039-S)
  • Spanish Ministry of Universities

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