Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to Aspergillus fumigatus Virulence
Authors:
- Uxue Perez-CuestaUPUxue Perez-Cuesta
- Xabier GuruceagaXGXabier Guruceaga
- Saioa Cendon-SanchezSCSaioa Cendon-Sanchez
- Eduardo Pelegri-MartinezEPEduardo Pelegri-Martinez
- Fernando L. HernandoFHFernando L. Hernando
- Andoni Ramirez-GarciaARAndoni Ramirez-Garcia
- Ana Abad-Diaz-De-CerioAAAna Abad-Diaz-De-Cerio
- Aitor RementeriaAitor Rementeria
Open Access
- 28 June 2021
- journal article
- review article
- Published by MDPI AG in Journal of Fungi
- Vol. 7 (7) , 518
Abstract
Aspergillus fumigatus is a ubiquitous soil decomposer and an opportunistic pathogen that is characterized by its large metabolic machinery for acquiring nutrients from media. Lately, an ever-increasing number of genes involved in fungal nutrition has been associated with its virulence. Of these, nitrogen, iron, and zinc metabolism-related genes are particularly noteworthy, since 78% of them have a direct implication in virulence. In this review, we describe the sensing, uptake and regulation process of the acquisition of these nutrients, the connections between pathways and the virulence-implicated genes. Nevertheless, only 40% of the genes mentioned in this review have been assayed for roles in virulence, leaving a wide field of knowledge that remains uncertain and might offer new therapeutic and diagnostic targets.Keywords
Funding Information
- Eusko Jaurlaritza (IT1362-19)
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