Zn-Mediated Reduction of Oxalyl Chloride Forming CO and Its Application in Carbonylation Reactions
- 10 November 2015
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 17 (22) , 5618-5621
Abstract
An efficient protocol for the generation of carbon monoxide by Zn-mediated reduction of oxalyl chloride has been developed. Oxalyl chloride was applied as an extremely effective substitute for toxic gaseous CO in the palladium-catalyzed alkoxy-/amino-/hydrogen-/hydroxycarbonylation processes providing industrially interesting esters, amides, aldehydes, and carboxylic acids in good to excellent yields. This new procedure can be applied to various carbonylation reactions in the presence of a transition metal catalyst under mild conditions and with a stoichiometric amount of CO source.Keywords
Funding Information
- Agentúra na Podporu Výskumu a Vývoja (14-0147)
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV (1/0488/14)
- European Commission (26240120001, 26240120025)
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