Opsonizing activity of G‐reactive protein in phagocytosis of Aspergillus fumigatus conidia by human neutrophils

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Abstract
Summary. In complement‐free neutrophil mono‐layer assays pathological levels of C‐reactive protein (CRP) were found to promote greater phagocytosis of metabolically‐active conidia of Aspergillus fumigatus than dormant spores. This suggests that metabolically‐active conidia bind CRP which facilitates in vitro phagocytosis by human neutrophils.Zusammenfassung. In komplementfreien Mo‐nolayer‐Zellkulturen neutrophiler Granulozyten wurden pathologische Werte an C‐reaktivem Protein (CRP) beobachtet, wenn ‐ im Gegensatz zu ruhenden Sporen ‐ stoffwechselaktive Konidien von Aspergillus fumigatus stärkere Phagozytose‐Aktivi‐tät bewirkten. Dies spricht dafür, daß stoffwechselaktive Konidien CRP binden, was die Phagozytose durch menschliche Neutrophile in vitro fördert.

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