Artesunate promotes intestinal epithelial barrier repair by facilitating HMGCS2-dependent ketogenesis in experimental ulcerative colitis model mice
Open Access
- 3 July 2025
- journal article
- Published by Elsevier in International Immunopharmacology
- Vol. 162, 115152
Abstract
No abstract availableKeywords
Funding Information
- Science and Technology Program of Zhejiang Province (2025ZR154)
- Natural Science Foundation of Beijing Municipality (5222003, 7172021, 5222004, 5242002)
- National Natural Science Foundation of China (31801011, 32071180)
This publication has 47 references indexed in Scilit:
- Artesunate—multiple pharmacological effects beyond treating malariaEuropean Journal of Medicinal Chemistry, 2025
- Ketone bodies rescue T cell impairments induced by low glucose availabilityEuropean Journal of Nutrition, 2024
- Oral delivery of chitosan-coated PLGA nanoemulsion loaded with artesunate alleviates ulcerative colitis in miceColloids and Surfaces B: Biointerfaces, 2022
- Ketogenesis alleviates TNFα-induced apoptosis and inflammatory responses in intestinal cellsFree Radical Biology and Medicine, 2021
- Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 CellsCell, 2020
- Artesunate targets oral tongue squamous cell carcinoma via mitochondrial dysfunction-dependent oxidative damage and Akt/AMPK/mTOR inhibitionJournal of Bioenergetics and Biomembranes, 2020
- Artesunate ameliorates DSS-induced ulcerative colitis by protecting intestinal barrier and inhibiting inflammatory responseInflammation, 2020
- Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to DietCell, 2019
- Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and TherapeuticsCell Metabolism, 2017
- Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivoAtherosclerosis, 2011