The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management
Open Access
- 22 February 2019
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Oncology
- Vol. 9, 75
Abstract
Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having immuno-modulating properties. This bacterium is an example of a microorganism inducing gastric cancer. Its carcinogenicity depends on bacteria-host related factors. The proper understanding of the biology of HP inducing gastric cancer offers the potential strategy in the managing of HP rather than eradicating it. In this article, we try to summarize the biology of HP-induced gastric cancer and discuss the current pharmacological approach to treat and prevent its carcinogenicity.Keywords
This publication has 213 references indexed in Scilit:
- Helicobacter pylori CagL Activates ADAM17 to Induce Repression of the Gastric H, K-ATPase α SubunitGastroenterology, 2010
- Helicobacter pylori: gastric cancer and beyondNature Reviews Cancer, 2010
- The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cellsEMBO Reports, 2009
- Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori-Induced ApoptosisGastroenterology, 2009
- Transgenic expression ofHelicobacter pyloriCagA induces gastrointestinal and hematopoietic neoplasms in mouseProceedings of the National Academy of Sciences, 2008
- Epidermal growth factor receptor mutations in lung cancerNature Reviews Cancer, 2007
- An African origin for the intimate association between humans and Helicobacter pyloriNature, 2007
- Who are we?EMBO Reports, 2006
- Helicobacter pylori and gastrointestinal tract adenocarcinomasNature Reviews Cancer, 2002
- Interleukin-1 polymorphisms associated with increased risk of gastric cancerNature, 2000