Correlation of Plasma Clearance of 54 Extensively Metabolized Drugs Between Humans and Rats: Mean Allometric Coefficient of 0.66
Authors:
- 1 September 1998
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 15 (9) , 1474-1479
Abstract
Purpose. To evaluate the distribution of allometric exponents for relationship of total plasma clearance of 54 extensively metabolized drugs, with wide-ranging linear clearance values, between humans...Keywords
This publication has 27 references indexed in Scilit:
- Pharmacokinetics and plasma protein binding of tamsulosin hydrochloride in rats, dogs, and humans.1998
- Comparative Pharmacokinetics and Interspecies Scaling of Amphotericin B in Several Mammalian SpeciesJournal of Pharmacy and Pharmacology, 1997
- Sex-dependent pharmacokinetics of indinavir: in vivo and in vitro evidence.Drug Metabolism and Disposition, 1996
- Interspecies scaling: predicting clearance of drugs in humans. Three different approachesXenobiotica, 1996
- Unbound Total (Plasma) Clearance Approach in Interspecies Pharmacokinetics Correlation: Theophylline-Cimetidine InteractionPharmaceutical Research, 1995
- Intravenous verapamil kinetics in rats: Marked arteriovenous concentration difference and comparison with humansBiopharmaceutics & Drug Disposition, 1993
- Comparative kinetics of sematilide in four species.Drug Metabolism and Disposition, 1993
- The Phenomenon and Rationale of Marked Dependence of Drug Concentration on Blood Sampling SiteClinical Pharmacokinetics, 1989
- Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in ratsJournal of Pharmacokinetics and Biopharmaceutics, 1985
- Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1982