IBX-Promoted Oxidative Cyclization of N-Hydroxyalkyl Enamines: A Metal-Free Approach toward 2,3-Disubstituted Pyrroles and Pyridines
- 22 May 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 85 (12) , 7939-7951
Abstract
An IBX-mediated selected oxidative cyclization of N-hydroxyalkyl enamines was developed. Through this strategy, a variety of 2,3-disubstituted pyrroles and pyridines were produced in good selectivity involving oxidation of alcohol, followed by condensation of aldehyde and α-C of enamines. Furthermore, this metal-free method has several advantages, including the use of environment-friendly reagents, broad substrate scope, mild reaction conditions and high efficiency.Keywords
Funding Information
- Baoji University of Arts And Sciences (2018XJ032)
- China Postdoctoral Science Foundation (2019T120936)
- National Natural Science Foundation of China (21622203)
- Natural Science Foundation of Shaanxi Province (2019JQ-274)
- Shaanxi Province (19JS004)
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