ORAL GIANT CELL GRANULOMAS A Clinical and Histological Study of 129 New Cases

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Abstract
Ninety‐seven peripheral and 32 central oral giant cell granulomas have been studied clinically and histologically. The distribution according to age (below and over 15 years of age) is similar in the two types of granulomas. It applies to both lesions that the prevalence usually is higher in females than in males. Both granulomas are most frequently found in the mandible. The central giant cell granuloma occur anterior to the molar region. The recurrence rate of the lesions in this material is high as compared with that observed in earlier studies. The radiographic features are non‐specific. The histopathology of the peripheral and central giant cell granulomas is fundamentally identical, both being composed of 1) a highly vascular and cellular granulation tissue containing, 2) a great number of multi‐nuclear giant cells of foreign body type scattered in the tissue, 3) extravasation by red blood cells and the presence of haemosiderin, 4) occasionally bone formation, and 5) several mitoses in the stromal cells. Comparative statistical analysis of the clinical findings and comparative histomorphological evaluation of the present material suggest that both types of lesions are manifestations of the same pathological condition.

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