Hepatocellular carcinoma: Short‐term reproducibility of apparent diffusion coefficient and intravoxel incoherent motion parameters at 3.0T

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Abstract
Purpose: To evaluate short‐term test–retest and interobserver reproducibility of IVIM (intravoxel incoherent motion) diffusion parameters and ADC (apparent diffusion coefficient) of hepatocellular carcinoma (HCC) and liver parenchyma at 3.0T.Materials and Methods: In this prospective Institutional Review Board (IRB)‐approved study, 11 patients were scanned twice using a free‐breathing single‐shot echo‐planar‐imaging, diffusion‐weighted imaging (DWI) sequence using 4 b values (b = 0, 50, 500, 1000 s/mm2) and IVIM DWI using 16 b values (0–800 s/mm2) at 3.0T. IVIM parameters (D: true diffusion coefficient, D*: pseudodiffusion coefficient, PF: perfusion fraction) and ADC (using 4 b and 16 b) were calculated. Short‐term test–retest and interobserver reproducibility of IVIM parameters and ADC were assessed by measuring correlation coefficient, coefficient of variation (CV), and Bland–Altman limits of agreements (BA‐LA).Results: Fifteen HCCs were assessed in 10 patients. Reproducibility of IVIM metrics in HCC was poor for D* and PF (mean CV 60.6% and 37.3%, BA‐LA: −161.6% to 135.3% and −66.2% to 101.0%, for D* and PF, respectively), good for D and ADC (CV 19.7% and J. Magn. Reson. Imaging 2015;41:149–156. © 2014 Wiley Periodicals, Inc.

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