Highly magnetic iron carbide nanoparticles as effective T2contrast agents
Authors:
- 8 November 2013
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Nanoscale
- Vol. 6 (2) , 726-730
Abstract
This paper reports that iron carbide nanoparticles with high air-stability and strong saturation magnetization can serve as effective T2 contrast agents for magnetic resonance imaging. Fe5C2 nanoparticles (∼20 nm in diameter) exhibit strong contrast enhancement with an r2 value of 283.2 mM−1 S−1, which is about twice as high as that of spherical Fe3O4 nanoparticles (∼140.9 mM−1 S−1). In vivo experiments demonstrate that Fe5C2 nanoparticles are able to produce much more significant MRI contrast enhancement than conventional Fe3O4 nanoparticles in living subjects, which holds great promise in biomedical applications.Keywords
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