A convenient approach to 2,4-disubstituted quinazoline-3-oxides using active MnO2 as the oxidant
Authors:
- 1 September 2019
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 97 (9) , 682-689
Abstract
Using cheap, readily available, and economic active MnO2 as an oxidant, a series of 2,4-disubstituted quinazoline-3-oxides were synthesized in good to excellent yields by oxidation of the corresponding 1,2-dihydroquinazoline-3-oxides under mild conditions. This novel approach is simple and convenient and provides a series of 2,4-disubstituted quinazoline-3-oxides.Keywords
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