Anti-genotoxic effect ofOcimum sanctumL. extract against cyproterone acetate induced genotoxic damage in cultured mammalian cells

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Abstract
The anti-genotoxic effect of \ud Ocimum sanctum\ud L. extract was studied against the genotoxic effect induced\ud by a synthetic progestin cyproterone acetate, on human lymphocytes using chromosomal aberrations,\ud mitotic index, sister chromatid exchanges and replication index as a parameters. About 30 \ud μ\ud M of cypro-\ud terone acetate was treated with \ud O. sanctum\ud L. infusion, at dosages of 1.075 × 10\ud –4\ud , 2.125 × 10\ud –4\ud and\ud 3.15 × 10\ud –4\ud g/ml of culture medium. A clear dose-dependent decrease in the genotoxic damage of cypro-\ud terone acetate was observed, suggesting a possible modulating role of the plant infusion. The results of\ud the present study suggest that the plant infusion \ud per se\ud does not have genotoxic potential, but can mod-\ud ulate the genotoxicity of cyproterone acetate on human lymphocytes \ud in vitro

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