Quantitative Determination of Immunoglobulins in CSF and Plasma of Chronic Schizophrenic Patients

Authors:
  • LDLynn E. Delisi
    Lynn E. Delisi
  • DWDaniel R. Weinberger
    Daniel R. Weinberger
  • LNLeonard M. Neckers
    Leonard M. Neckers
  • DSDavid J. Shiling
    David J. Shiling
  • RWRichard Jed Wyatt
    Richard Jed Wyatt
Publisher website
Google Scholar
Abstract
Summary: Immunoglobulins, IgG, IgA and IgM were quantified in cerebrospinal fluid (CSF) and plasma from chronic schizophrenic patients and controls using an immunofluorescent antibody technique. A generalized reduction in immunoglobulin levels was observed in the schizophrenic patients compared with controls. While this study supports other reports of abnormal immune functioning in schizophrenia, it failed to replicate previous findings of elevations in CSF IgG and elevations in serum IgA. The aetiology and significance of these findings are hypothesized but remain elusive.

This publication has 39 references indexed in Scilit: