Three new lignanamides from the root of Lycium chinense with anti-inflammatory activity
- 30 May 2018
- journal article
- research article
- Published by Taylor & Francis in Natural Product Research
- Vol. 33 (23) , 3378-3382
Abstract
Three new lignanamides, that is, a new lignanamide (1), and a pair of enantiomers (2a and 2b) were isolated from the EtOAc-soluble fraction of an EtOH extract of the root of Lycium chinense. The structures of these new compounds, including their absolute configuration, were established on the basis of HR-ESI-MS, NMR spectroscopic data and quantum chemical ECD calculations. Compound 2a showed significant anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC50 value of 10.77 ± 2.14 μM, comparing to that of positive control quercetin (17.21 ± 0.50 μM).Keywords
Funding Information
- National Natural Science Foundation of China (81573578)
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