Sensory and Motor Functions of Spinal Cord Substance P
Authors:
- 18 December 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 214 (4527) , 1361-1363
Abstract
Low doses of D-Pro 2 -D-Phe 7 -D-Trp 9 -substance P, a specific substance P antagonist, depressed the scratching and biting behaviors elicited by intrathecal injections of substance P, and cutaneous application of algesic substances. Higher antagonist doses caused hindlimb paralysis. This suggests that substance P is a neurotransmitter for primary nociceptor afferents and may also have an important function in motor control.Keywords
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