Naringen's Effects on Diuresis and Prevention of Urolithiasis in Hypertensive Rats

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Abstract
This research demonstrates the diuretic effect of naringenin, a flavanone aglycone found in citrus, on spontaneously hypertensive female and male rats (SHR). The data reinforces existing literature findings that male SHR exhibits higher systolic blood pressure than age‐matched females. Urine volume assessed over 8 hours was lower when obtained from SHR males than females. When these animals were orally treated with different doses of naringenin (0.1–1 mg/kg), this increased urinary volume in both genders at the highest dose tested. In contrast, the lowest dose promoted a significant natriuretic effect. The other electrolytes analyzed in urine were not significantly altered, except potassium excretion, which was shown to be increased in the urine of SHR males. Furthermore, naringenin showed promise in reducing calcium oxalate (CaOx) crystal formation in an in vitro model, presenting potential advantages in lithiasis prevention.
Funding Information
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (001)
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (001)
  • Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (2021TR001783)

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