ALS-associated A315E and A315pT variants exhibit distinct mechanisms in inducing irreversible aggregation of TDP-43 312–317 peptides
- 15 June 2022
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Physical Chemistry Chemical Physics
- Vol. 24 (26) , 16263-16273
Abstract
ALS-associated A315E and A315pT variants induce irreversible aggregation of TDP-43 312–317 by decreasing peptide fluidity and increasing intermolecular interactions via different mechanisms.Keywords
Funding Information
- Natural Science Foundation of Shanghai Municipality (22ZR1406800)
- National Natural Science Foundation of China (12074079)
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