INFLUENCE OF THYROID ON FORMATION OF MYELIN LIPIDS 1

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Abstract
—The formation of lipids found primarily in the myelin sheath was investigated in rats made hypothyroid, at birth. A marked reduction in cerebroside, sulphatide, and cholesterol of brains was found in 18‐day‐old hypothyroid animals. These lipids were also reduced, although to a lesser degree, in 30‐day‐old ex‐hypothyroid animals allowed to return to the euthyroid state at age 18 days.The onset of formation of sulphatide in vivo was delayed in the hypothyroid animals. Sulphatide formation reached a peak at a later time and was greatly reduced in comparison to control animals. The activity in vitro of galactolipid sulphotransferase, which forms sulphatide from cerebroside and PAPS, was reduced only when exogenous PAPS was not added to the assay medium. This finding suggests a defect in the formation of PAPS from ATP and sulphate in the hypothyroid brain. In addition, T3 (tri‐iodothyronine) had a stimulatory effect in vivo of formation brain sulphatide when administered to rats during the first 5 days of life.

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