Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors
Authors:
- 1 April 2005
- journal article
- Published by Elsevier in Cancer Cell
- Vol. 7 (4) , 325-336
Abstract
No abstract availableKeywords
This publication has 52 references indexed in Scilit:
- The RAB25 small GTPase determines aggressiveness of ovarian and breast cancersNature Medicine, 2004
- Apoptotic and Cytostatic Farnesyltransferase Inhibitors Have Distinct Pharmacology and Efficacy Profiles in Tumor ModelsCancer Research, 2004
- Crystal Structures of the Anticancer Clinical Candidates R115777 (Tipifarnib) and BMS-214662 Complexed with Protein Farnesyltransferase Suggest a Mechanism of FTI SelectivityBiochemistry, 2004
- Death and more: DNA damage response pathways in the nematode C. elegansCell Death & Differentiation, 2003
- Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1Oncogene, 2003
- Protein farnesyltransferase inhibitorsExpert Opinion on Emerging Drugs, 2003
- Regulation of Membrane Transport by rab GTPasesCritical Reviews in Biochemistry and Molecular Biology, 2003
- Double Prenylation by RabGGTase Can Proceed without Dissociation of the Mono-prenylated IntermediateJournal of Biological Chemistry, 2001
- The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosisCurrent Biology, 2001
- Mechanism of Digeranylgeranylation of Rab ProteinsJournal of Biological Chemistry, 1996