Cu/N,N′-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines

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Abstract
N,N′-Dibenzyloxalamide (DBO) was identified as a powerful ligand for promoting Cu-catalyzed coupling of heteroanilines with (hetero)aryl halides. For (hetero)aryl chlorides, the coupling reaction occurred at 130 °C with 5 mol % CuBr and 10 mol % DBO. For (hetero)aryl bromides/iodides, coupling reaction took place at 80–100 °C with 1 mol % CuI and 2 mol % DBO. A variety of heteroanilines worked well to afford the arylation products in good to excellent yields.
Funding Information
  • National Natural Science Foundation of China (21831009, 21621002)
  • Chinese Academy of Sciences (XDB20020200, QYZDJ-SSW-SLH029)

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