MicroRNA-29a regulates pro-inflammatory cytokine secretion and scavenger receptor expression by targeting LPL in oxLDL-stimulated dendritic cells
Authors:
- Zhoubin LiZLZhoubin Li
- Jing TuJTJing Tu
- Weiguo ZhuWZWeiguo Zhu
- Junhua GeJGJunhua Ge
- Xiaoye ZhengXZXiaoye Zheng
- Lin YangLYLin Yang
- Xiaoping PanXPXiaoping Pan
- Hui YanHYHui Yan
- Jianhua ZhuJZJianhua Zhu
- 4 February 2011
- journal article
- Published by Wiley in FEBS Letters
- Vol. 585 (4) , 657-663
Abstract
There is increasing evidence that microRNAs (miRNAs) play important roles in cell proliferation, apoptosis and differentiation that accompany inflammatory responses. However, whether microRNAs are associated with DC immuno-inflammatory responses with oxidized low density lipoprotein (oxLDL) stimulation is not yet known. Our study aims to explore the link of miRNAs with lipid-overload and immuno-inflammatory mechanism for atherosclerosis. In DCs transfected with microRNA-29a mimics or inhibitors, we showed that microRNA-29a plays an important role in proinflammatory cytokine secretion and scavenger receptor expression upon oxLDL-treatment. Furthermore, we suggest an additional explanation for the mechanism of microRNA-29a regulation of its functional target, lipoprotein lipase. We conclude that microRNA-29a could regulate pro-inflammatory cytokine secretion and scavenger receptor expression by targeting lipoprotein lipase in oxLDL-stimulated dendritic cells.Keywords
Funding Information
- Zhejiang Provincial Natural Science (Y2100372)
- National Natural Science Foundation of China (30370570/C03030201, 30670866/C03030201)
This publication has 32 references indexed in Scilit:
- Dendritic cells in atherosclerotic diseaseClinical Immunology, 2010
- MicroRNAs Are Aberrantly Expressed in Hypertrophic HeartThe American Journal of Pathology, 2007
- MicroRNAs Play an Essential Role in the Development of Cardiac HypertrophyCirculation Research, 2007
- Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 ComplexCell, 2006
- Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.Genes & Development, 2006
- Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAsRNA, 2004
- MicroRNA genes are transcribed by RNA polymerase IIThe EMBO Journal, 2004
- Inflammation in atherosclerosisNature, 2002
- Immune Mechanisms in AtherosclerosisArteriosclerosis, Thrombosis, and Vascular Biology, 2001
- The vascular-associated lymphoid tissue: a new site of local immunityCurrent Opinion in Lipidology, 2001