A Nondeletional Mechanism of Thymic Self Tolerance
Authors:
- 24 November 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 246 (4933) , 1038-1041
Abstract
T cells become tolerant of self antigens during their development in the thymus. Clonal deletion of thymocytes bearing self-reactive T cell receptors is a major mechanism for generating tolerance and occurs readily for antigens expressed by bone marrow-derived cells. Tolerance to antigens expressed on the radioresistant thymic stromal elements is demonstrated here to occur via a nondeletional mechanism. For minor lymphocyte stimulatory (Mls-1 a ) and major histocompatibility complex (MHC) antigens, this alternate form of tolerance induction results in clonal anergy.Keywords
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