Diphenylhydantoin: Action of a Common Anticonvulsant on Bursting Pacemaker Cells in Aplysia
Authors:
- 19 September 1975
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 189 (4207) , 1009-1011
Abstract
A commonly used anticonvulsant, diphenylhydantoin (Dilantin), decreases the bursting pacemaker activity in certain cells of Aplysia. Dilantin decreases this bursting activity whether it is endogenous to the cell or induced by a convulsant agent. The sodium-dependent negative resistance characteristic which is essential for bursting behavior is reduced in the presence of Dilantin.Keywords
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