Dapagliflozin attenuates AKI to CKD transition in diabetes by activating SIRT3/PGC1-α signaling and alleviating aberrant metabolic reprogramming
Authors:
- 26 July 2024
- journal article
- research article
- Published by Elsevier in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Vol. 1870 (7) , 167433
Abstract
No abstract availableKeywords
Funding Information
- National Natural Science Foundation of China (82200777, 82100803)
- Natural Science Foundation of Hunan Province (2023020201020505, 2022JJ40710)
- Natural Science Foundation of Hubei Province (2021CFB379, 2021CFB101)
This publication has 59 references indexed in Scilit:
- Comparing Effectiveness and Safety of SGLT2 Inhibitors vs DPP-4 Inhibitors in Patients With Type 2 Diabetes and Varying Baseline HbA1c LevelsJAMA Internal Medicine, 2023
- Sodium-Glucose Transport Protein 2 Inhibitor Use for Type 2 Diabetes and the Incidence of Acute Kidney Injury in TaiwanJAMA Network Open, 2023
- MiR-20a-5p alleviates kidney ischemia/reperfusion injury by targeting ACSL4-dependent ferroptosisAmerican Journal of Transplantation, 2023
- Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imagingActa Pharmaceutica Sinica B, 2021
- The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors?Kidney International, 2020
- The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trialKidney International, 2020
- Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th editionDiabetes Research and Clinical Practice, 2019
- Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and FibrosisCell Metabolism, 2019
- SIRT3 Mediates Multi-Tissue Coupling for Metabolic Fuel SwitchingCell Metabolism, 2015
- SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damageFree Radical Biology and Medicine, 2013