Curative Resection of T1 Colorectal Carcinoma: Risk of Lymph Node Metastasis and Long-Term Prognosis

Authors:
  • WLWen-Yih Liang
    Wen-Yih Liang
  • TLTzu-Chen Lin
    Tzu-Chen Lin
  • WCWei-Shone Chen
    Wei-Shone Chen
  • JJJeng-Kae Jiang
    Jeng-Kae Jiang
  • SYShung-Haur Yang
    Shung-Haur Yang
  • SCShih-Ching Chang
    Shih-Ching Chang
  • JLJen-Kou Lin
    Jen-Kou Lin
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Abstract
Ction of T1 colorectal adenocarcinoma at the Taipei Veterans General Hospital from December 1969 to August 2002 were retrospectively studied. Patients with synchronous colorectal cancer, distant metastasis, familiar adenomatous polyposis, or inflammatory bowel disease were excluded. The associations between lymph node metastasis and clinicopathologic variables were evaluated univariately using chi-squared test, Fisher's exact test, or Student'st-test, and multivariately using logistic regression. Univariate analysis by the log-rank test and multivariate analysis by Cox regression hazards model determined the factors influencing the overall survival. RESULTS: A total of 159 patients were included. Sixteen patients (10.1 percent) had lymph node metastasis. The risk of lymph node metastasis included histologic grade (P= 0.005), lymphatic vessel invasion (P= 0.023), inflammation around cancer (P= 0.049), and budding at the invasive front of tumor (P= 0.022). Age (P= 0.001) and number of total sampling lymph nodes (P< 0.0001) were found to be the factors influencing the overall survival. CONCLUSIONS: Variables that predict lymph node metastasis in surgically resected T1 colorectal carcinoma may not impact the long-term prognosis. Supported by a grant from the Research Foundation of Taipei Veterans General Hospital. aNo. 201, Sec. 2, Shih-Pai Road, Taipei, Taiwan, 11217, Republic of China, e-mail: hswang@vghtpe.gov.tw © The ASCRS 2005...

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