Lymphocyte Ecto-5′-Nucleotidase Deficiency in Agammaglobulinemia
Authors:
- 18 August 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 201 (4356) , 628-630
Abstract
Fresh peripheral blood lymphocytes from eight patients with congenital agammaglobulinemia demonstrate reduced ecto-5′-nucleotidase activity when compared to the mean activity of normal subjects and patients with other forms of immunoglobulin deficiency. A specific defect of ecto-5′-nucleotidase is further suggested by normal values for lymphocyte ecto-adenosinetriphosphatase and ecto-nonspecific phosphatase. The data provide evidence for an enzyme deficiency in this X-linked, B lymphocyte deficiency syndrome.Keywords
This publication has 27 references indexed in Scilit:
- Partial Purine Nucleoside Phosphorylase DeficiencyJournal of Clinical Investigation, 1978
- Purine Nucleoside Phosphorylase DeficiencyJournal of Clinical Investigation, 1977
- Purine Nucleoside Phosphorylase Deficiency Associated with Selective Cellular ImmunodeficiencyNew England Journal of Medicine, 1977
- Gene Dose Effect: Regional Mapping of Human Nucleoside Phosphorylase on Chromosome 14Science, 1976
- Human lymphocytes: 5'-nucleotidase-positive and -negative subpopulations.Journal of Clinical Investigation, 1975
- 5'-Nucleotidase from smooth muscle of small intestine and from brain. Inhibition by nucleotidesBiochemistry, 1975
- Molecular form of adenosine deaminase in severe combined immunodeficiencyBiochemical and Biophysical Research Communications, 1974
- Heterogeneity of 5′-Nucleotidase Activity in Lymphocytes in Chronic Lymphocytic LeukemiaJournal of Clinical Investigation, 1973
- The association of glucose phosphate isomerase expression with human chromosome 19 using somatic cell hybridsCytogenetic and Genome Research, 1973
- Binding of Sheep Red Blood Cells to a Large Population of Human LymphocytesNature, 1971