An Overview of Methotrexate Indications in Skin Diseases
Authors:
- Mădălina MocanuMMMădălina Mocanu
- Dorina ProcopciucDPDorina Procopciuc
- Dragoș-Florin Gheucă-SolovăstruDGDragoș-Florin Gheucă-Solovăstru
- Ioana Adriana PopescuIPIoana Adriana Popescu
- Doinița Temelie OliniciDODoinița Temelie Olinici
- Adriana Ionela PătrașcuAPAdriana Ionela Pătrașcu
- Dan VâțăDan Vâță
- Laura Gheucă-SolovăstruLGLaura Gheucă-Solovăstru
Open Access
Abstract
Methotrexate is an immunosuppressive drug with remarkable therapeutic results in the treatment of autoimmune and proliferative skin diseases. Although it has been more than half a century since it was first introduced into the therapeutic arsenal of dermatologists, there are currently no standardized therapeutic protocols regarding the prescription of methotrexate in dermatology, with the exception of psoriasis treatment. This review aims to highlight the indications and benefits of methotrexate beyond psoriasis, with a focus on a wide range of inflammatory, vesiculobullous, and proliferative dermatological pathologies.Keywords
This publication has 73 references indexed in Scilit:
- Methotrexate therapy for ocular cicatricial pemphigoid*1Ophthalmology, 2004
- Low-dose methotrexate to treat mycosis fungoides: a retrospective study in 69 patientsJournal of the American Academy of Dermatology, 2003
- Methotrexate treatment for refractory subacute cutaneous lupus erythematosusJournal of the American Academy of Dermatology, 2002
- Do patients with rheumatoid arthritis established on methotrexate and folic acid 5 mg daily need to continue folic acid supplements long term?Rheumatology, 2000
- Methotrexate in psoriasis: 26 years’ experience with low‐dose long‐term treatmentJournal of the European Academy of Dermatology and Venereology, 2000
- Suppression of TNF-α production in human mononuclear cells by an adenosine kinase inhibitorJournal of Leukocyte Biology, 2000
- Anti-arthritic effect of methotrexate: is it really mediated by adenosine?European Journal of Pharmaceutical Sciences, 2000
- OLD, NEW, AND EMERGING THERAPIES FOR ATOPIC DERMATITISDermatologic Clinics, 2000
- Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells.Journal of Clinical Investigation, 1998
- Adult pityriasis rubra pilaris: A 10-year case seriesJournal of the American Academy of Dermatology, 1997