Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells
Open Access
- 16 August 2007
- journal article
- Published by Springer Nature in BMC Neuroscience
- Vol. 8 (1) , 67
Abstract
Many studies have shown that mitochondrial dysfunction, complex I inhibition in particular, is involved in the pathogenesis of Parkinson's disease (PD). Rotenone, a specific inhibitor of mitochondrial complex I, has been shown to produce neurodegeneration in rats as well as in many cellular models that closely resemble PD. However, the mechanisms through which complex I dysfunction might produce neurotoxicity are as yet unknown. A comprehensive analysis of the mitochondrial protein expression profile affected by rotenone can provide important insight into the role of mitochondrial dysfunction in PD.Keywords
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