Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2
Open Access
- 11 April 2014
- journal article
- research article
- Published by Springer Nature in Cell & Bioscience
- Vol. 4 (1) , 18
Abstract
The human ether-a-go-go-related gene potassium channel (hERG) has an unusual long turret, whose role in recognizing scorpion toxins remains controversial. Here, BmKKx2, the first specific blocker of hERG channel derived from scorpion Mesobuthus martensii, was identified and the turret role of hERG channel was re-investigated using BmKKx2 as a molecular probe.Keywords
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