Understanding the mechanisms and translational implications of the microbiome for cancer therapy innovation
- 31 July 2023
- journal article
- review article
- Published by Springer Nature in Nature Cancer
- Vol. 4 (8) , 1083-1094
Abstract
The intersection of the microbiota and cancer and the mechanisms that define these interactions are a fascinating, rapidly evolving area of cancer biology and therapeutics. Here we present recent insights into the mechanisms by which specific bacteria or their communities contribute to carcinogenesis and discuss the bidirectional interplay between microbiota and host gene or epigenome signaling. We conclude with comments on manipulation of the microbiota for the therapeutic benefit of patients with cancer.Keywords
Funding Information
- Cancer Research UK (the Cancer Grand Challenges OPTIMISTICC team grant [A27140])
- Bloomberg Philanthropies
- Burroughs Wellcome Fund (1022128)
- the Biocodex Microbiota Foundation, The Pearl M. Stetler Award, and the Black in Cancer Award funded by the Emerald Foundation
- U.S. Department of Health & Human Services | NIH | National Cancer Institute (K08CA263316-02)
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