A Comparison of Recombinant Hirudin with Heparin for the Treatment of Acute Coronary Syndromes
Author:
- The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb InvestigatorsTIThe Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators
Open Access
- 12 September 1996
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 335 (11) , 775-782
Abstract
Thrombin has a pivotal role in the pathogenesis of acute coronary thrombosis. We compared the clinical efficacy of a potent, direct thrombin inhibitor, recombinant hirudin, with that of heparin (an indirect antithrombin agent) in patients with unstable angina or acute myocardial infarction.Keywords
This publication has 22 references indexed in Scilit:
- Coronary Plaque DisruptionCirculation, 1995
- Initial experience withhirudin andstreptokinase in acute myocardial infarction: Results of the thrombolysis in myocardial infarction (TIMI) 6 trialThe American Journal of Cardiology, 1995
- Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology.Circulation, 1994
- Direct thrombin inhibitors in cardiovascular medicine.Circulation, 1994
- Recombinant hirudin for unstable angina pectoris. A multicenter, randomized angiographic trial.Circulation, 1994
- Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction. Results of the TIMI IIIB Trial. Thrombolysis in Myocardial Ischemia.Circulation, 1994
- A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trialJACC, 1994
- HeparinNew England Journal of Medicine, 1991
- Aspirin, Heparin, or Both to Treat Acute Unstable AnginaNew England Journal of Medicine, 1988
- Insights into the pathogenesis of acute ischemic syndromes.Circulation, 1988