Bisubstrate Inhibitors of the Enzyme Catechol O‐Methyltransferase (COMT): Efficient Inhibition Despite the Lack of a Nitro Group
- 2 September 2004
- journal article
- research article
- Published by Wiley in ChemBioChem
- Vol. 5 (9) , 1270-1274
Abstract
No abstract availableKeywords
This publication has 38 references indexed in Scilit:
- Molecular Modeling and Metabolic Studies of The Interaction of Catechol-O-Methyltransferase and a New Nitrocatechol InhibitorDrug Metabolism and Disposition, 2003
- Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol-O-methyltransferase inhibitorEuropean Journal of Pharmacology, 2003
- A Highly Significant Association between a COMT Haplotype and SchizophreniaThe American Journal of Human Genetics, 2002
- Kinetics and Crystal Structure of Catechol-O-Methyltransferase Complex with Co-Substrate and a Novel Inhibitor with Potential Therapeutic ApplicationMolecular Pharmacology, 2002
- Prefrontal neurons and the genetics of schizophreniaBiological Psychiatry, 2001
- COMT and schizophrenia: biology meets geneticsTrends in Biotechnology, 2001
- Crystal structure of catechol O-methyltransferaseNature, 1994
- Catechol‐O‐methyltransferase‐Inhibiting Pyrocatechol Derivatives: Synthesis and Structure‐Activity StudiesHelvetica Chimica Acta, 1989
- Pharmacokinetics of LevodopaClinical Neuropharmacology, 1984
- Biochemistry of CatecholaminesAnnual Review of Biochemistry, 1971