A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab
Open Access
- 18 February 2019
- journal article
- research article
- Published by Wiley in CPT: Pharmacometrics & Systems Pharmacology
- Vol. 8 (7) , 444-459
Abstract
Physiologically based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, coding of a PBPK model in a mathematical programming language can be challenging. This tutorial illustrates how to build a whole‐body PBPK model in Matlab® to answer specific pharmacological questions involving drug disposition, and magnitudes of drug‐drug interactions in different patient populations.Keywords
This publication has 59 references indexed in Scilit:
- Co‐administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjectsBritish Journal of Clinical Pharmacology, 2013
- Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and DevelopmentCPT: Pharmacometrics & Systems Pharmacology, 2013
- Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug DevelopmentBioMed Research International, 2011
- A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug ClearanceClinical Pharmacokinetics, 2010
- Population-Based Mechanistic Prediction of Oral Drug AbsorptionThe AAPS Journal, 2009
- Characterizing Uncertainty and Variability in Physiologically Based Pharmacokinetic Models: State of the Science and Needs for Research and ImplementationToxicological Sciences, 2007
- Effect of Rifampin on Steady-State Pharmacokinetics of Atazanavir with Ritonavir in Healthy VolunteersAntimicrobial Agents and Chemotherapy, 2006
- A Mechanistic Approach for the Scaling of Clearance in ChildrenClinical Pharmacokinetics, 2006
- Prediction of the Clearance of Eleven Drugs and Associated Variability in Neonates, Infants and ChildrenClinical Pharmacokinetics, 2006
- Prediction of Pharmacokinetics Prior to In Vivo Studies. II. Generic Physiologically Based Pharmacokinetic Models of Drug DispositionJournal of Pharmaceutical Sciences, 2002