Identification of a quality-control factor that monitors failures during proteasome assembly
- 27 August 2021
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 373 (6558) , 998-1004
Abstract
Safeguarding protein complex assembly: The assembly of multiprotein complexes inside the cell requires each subunit to be produced at a defined level relative to its partners. Imbalances in subunit synthesis are inevitable, necessitating the elimination of unassembled intermediates. Zavodszky et al . found that a ubiquitin ligase called HERC1 is responsible for marking certain assembly intermediates of the proteasome for degradation. HERC1 finds these intermediates by recognizing a proteasome assembly factor that normally dissociates when assembly is complete. A point mutation in HERC1 that impairs its ability to recognize proteasome assembly intermediates causes neurodegeneration in mice, highlighting the importance of this quality control pathway. —SMHKeywords
Funding Information
- Medical Research Council (MC_ UP_A022_1007)
- LMB-AZ BlueSky Fund (BSF27)
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