PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines
- 21 August 2007
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Green Chemistry
- Vol. 9 (11) , 1185-1190
Abstract
The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a ‘one pot’ procedure. The intermediate Claisen–Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.Keywords
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