Halogen Atom Transfer Enabled Radical Fluoroalkyl‐Thiolation of Unactivated Alkenes

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Abstract
A halogen atom transfer‐enabled radical fluoroalkyl‐thiolation of unactivated alkenes is developed employing fluoroalkyl iodides, TMEDA‐ligated zinc thiolates. Notably, the aryldiazonium salts are utilized as the promoter in the three‐component reaction, providing a powerful tool for simultaneous construction of CRf and CS bonds across the CC bond. Moreover, direct thiolation of fluoroalkyl iodides without alkene gives the two‐component reaction products. Mechanistic studies support that the interaction between diazonium salt and zinc thiolate plays a crucial role in the transformations.
Funding Information
  • National Natural Science Foundation of China (22001051)
  • National Natural Science Foundation of China (22371061)
  • Basic and Applied Basic Research Foundation of Guangdong Province (2024A1515010323)
  • Basic and Applied Basic Research Foundation of Guangdong Province (2025A1515011907)

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