Conversion of Beta Sitosterol to Cholesterol Blocked in an Insect by Hypocholesterolemic Agents
Authors:
- 23 June 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 156 (3782) , 1637-1638
Abstract
Two vertebrate hypocholesterolemic agents (triparanol and 22,25-diazacholesterol) block the conversion of β-sitosterol to cholesterol in the larva of the tobacco hornworm, Manduca sexta (Johannson). A primary site of inhibitory action is the terminal step in this conversion—the reduction of desmosterol (24-dehydrocholesterol) to cholesterol. This is also the site at which these compounds inhibit de novo cholesterol biosynthesis in higher animals. Both agents severely inhibit growth and maturation of the tobacco hornworm.Keywords
This publication has 10 references indexed in Scilit:
- Conversion of β-Sitosterol, to Cholesterol in the Boll Weevil and the Inhibition of Larval Development by Two Aza Sterols12Journal of Economic Entomology, 1967
- Desmosterol, an intermediate in dealkylation of β-sitosterol in the tobacco hornwormLife Sciences, 1967
- Studies on the Sterol of Bombyx mori L. IV. Conversion of the Sterol in the Silkworm.Chemical and Pharmaceutical Bulletin, 1966
- The relationship of the sterols of the Virginia pine sawfly, Neodiprion pratti Dyar, to those of two host plants, Pinus virginiana Mill and Pinus rigida MillJournal of Insect Physiology, 1965
- The utilization and fate of β-sitosterol in the larva of the housefly, Musca domestica L.Journal of Insect Physiology, 1965
- Effect of 22,25-Diazacholestanol on Synthesis of Cholesterol by Rat Liver HomogenatesExperimental Biology and Medicine, 1964
- The sterols of liver and carcass of 20,25-diaza-cholesterol-fed ratsSteroids, 1963
- The Fate of Dietary H3-β-Sitosterol in the Adult House Fly1Annals of the Entomological Society of America, 1963
- The Metabolism of H3-β-Sitosterol by the German Cockroach1Annals of the Entomological Society of America, 1962
- Mechanism of action of MER-29, an inhibitor of cholesterol biosynthesisBiochemical and Biophysical Research Communications, 1960