Severe proliferative diabetic retinopathy associated with acromegaly

Authors:
  • NINaoki Inokuchi
    Naoki Inokuchi
  • TITsunehiko Ikeda
    Tsunehiko Ikeda
  • FYFuyuko Yasuda
    Fuyuko Yasuda
  • SSSetuko Shirai
    Setuko Shirai
  • YUYasutaka Uchihori
    Yasutaka Uchihori
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Abstract
A 62 year old woman presented with severe proliferative diabetic retinopathy and was admitted to Osaka Kaisei Hospital for a pars plana vitrectomy. The duration of her diabetic mellitus was about 10 years and her blood sugar level was between 140–320 mg/ml. HgA1c was 7.0–7.5%. The patient also had systemic hypertension. Corrected visual acuity was 30 cm/hand movement in the right eye and light perception in her left eye. Remarkable bilateral rubeosis iridis, active fibrovascular membranes, and extensive tractional retinal detachment were observed in both eyes (Fig 1). Physical examination revealed acromegaly in all four limbs (Fig2A). The patient’s serum GH level was 256 ng/ml and her serum IGF-I level was 726 ng/ml. Magnetic resonance imaging revealed the presence of pituitary adenoma (Fig 2B). Based on these findings acromegaly was diagnosed.