Orthostatic and exercise intolerance in postacute sequelae of COVID-19 occur with intact sympathetic neural control and preserved cardiac reserve

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Muscle sympathetic nerve activity (MSNA), sympathetic baroreflex gain, and neurovascular transduction were intact in people with postacute sequelae of COVID-19 syndrome (PASC), and MSNA was recruited normally during head-up tilt. However, 41% of participants could not complete the tilt. Biventricular contractile reserve was likewise preserved. Symptoms that track neither sympathetic outflow nor systemic pressure localize the disturbance upstream, to afferent reflex control, or downstream to the cerebral circulation.
Funding Information
  • University of Melbourne (n/a)

This publication has 46 references indexed in Scilit: