Hyperprolactinaemia and reproductive health of women

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Abstract
Objective. Optimisation of pregravidal preparation of patients with various forms of hyperprolactinemia to increase reproductive potential. Material and methods. Prospective examination and treatment of 58 patients with different types of hyperprolactinemia were carried out. Depending on the type of hyperprolactinemia all patients were divided into 4 groups: patients with functional hyperprolactinemia, microadenoma and macroadenoma of pituitary gland and macroprolactinemia’s phenomenon. The examination of patients included a standard range of laboratory and instrumental investigations. Results. The peculiarities of menstrual cycle and reproductive function disorders, frequency of development of concomitant endocrine and somatic diseases in different forms of hyperprolactinemia were studied. As a result of complex pregravidal preparation of patients with hyperprolactinemia pregnancy occurred in 25 (86%) out of 29 women who planned it. At the same time, 11 (44%) patients became pregnant against the background of cabergoline treatment and 3—6 months after its cancellation, and 14 (56%) patients additionally underwent ovulation stimulation cycles. Conclusion. To restore the regulation of menstrual cycle and reproductive function in patients with hyperprolactinemia of different genesis it is reasonable to use dopamine agonists, gestagens, as well as estrogens and inducers of ovulation.

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